Serum Secretory IgA and IgM and Free Secretory Component in IgA Nephropathy
| Autor: | E. Renoult, M. Kessler, E. Seillès, Molé Cm, J.P. Revillard, Gilbert C. Faure, Marie-Christine Béné |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Immunoglobulin A Adolescent Secretory component Enzyme-Linked Immunosorbent Assay urologic and male genital diseases Nephropathy Immunopathology Humans Medicine Aged biology business.industry Glomerulonephritis IGA Glomerulonephritis Middle Aged medicine.disease J chain Secretory Component Immunoglobulin M Mesangium Immunoglobulin A Secretory Immunology biology.protein Female business Polymeric immunoglobulin receptor |
| Zdroj: | Nephron. 71:75-78 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | IgA nephropathy (IgAN) is characterized by the presence of IgA and C3 deposits in the mesangium. Mesangial IgA is mostly dimeric IgA1 with a J chain, lacking a secretory component. In view of the recent demonstration of elevated serum levels of secretory component and secretory IgA in liver disease and HIV infection associated with hyper-IgA, we measured the serum secretory component in 50 IgAN patients and 45 controls. Free secretory component and secretory IgA and IgM levels were determined by enzyme-linked immunosorbent assay. Normal or low levels were found patients. These data support previous work suggesting that in IgAN circulating and probably mesangial IgA do not originate from the epithelial compartment of the mucosal immunoglobulins as it is the case in other hyper-IgA diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|