Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis
| Autor: | Argentina Leon, Jordan D. Rosen, Takashi Hashimoto, Ralf Paus, Anna Chiara Fostini, Gil Yosipovitch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nervous system Sensory system Dermatology Biochemistry 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Medicine Humans Molecular Biology Neurogenic inflammation integumentary system business.industry Pruritus medicine.disease Mast cell Scalp itch 030104 developmental biology medicine.anatomical_structure Scalp Dermatoses Scalp Itching medicine.symptom Neurogenic Inflammation business Neuroscience |
| Zdroj: | Experimental dermatologyREFERENCES. 28(12) |
| ISSN: | 1600-0625 |
| Popis: | Scalp psoriatic itch is a common complaint and often poses a therapeutic challenge. The pathophysiology of this phenomenon is unclear. The unique anatomy of the scalp contains richly innervated hair follicles, abundant vasculature and perifollicular inflammatory cytokines which may all contribute to this common sensory complaint. The mast cell, in particular, is portrayed as one of the main itch conductors for its ability to trigger neurogenic inflammation, activate the peripheral hypothalamic-pituitary-adrenal-axis, process and integrate itch signalling through its interactions with the scalp hair follicles. Herein, we explain and speculate upon potential mechanisms underlying itchy scalp psoriasis, involving interconnections between the neuroimmune, neurovascular and neuroendocrine systems. Many factors may play roles in itchy scalp psoriasis including the scalp hair structure, immune system, endocrine system, nervous system and vascular system. These may warrant further exploration as therapeutic targets that go beyond the application of mere anti-inflammatory agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text