Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population

Autor:	Meng Wang, Xinghan Liu, Kang Liu, Tian Tian, Shuqun Zhang, Peng Xu, Huafeng Kang, Hai-Tao Guan, Zhijun Dai, Xi-Jing Wang, Yi Zheng, Pengtao Yang, Tianbo Jin, Di Liu
Rok vydání:	2017
Předmět:	Adult 0301 basic medicine Oncology China Aging medicine.medical_specialty Genotype Breast Neoplasms Subgroup analysis Biology Polymorphism Single Nucleotide polymorphism 03 medical and health sciences Tumor grade breast cancer 0302 clinical medicine Breast cancer Chinese han population Internal medicine medicine Humans Metallothionein Genetic Predisposition to Disease metallothionein 2A Promoter Regions Genetic Alleles Cell Biology Middle Aged medicine.disease 3. Good health Minor allele frequency 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Research Paper
Zdroj:	Aging (Albany NY)
ISSN:	1945-4589
DOI:	10.18632/aging.101177
Popis:	Genetic polymorphisms of MT2A are frequently observed in many different cancers. We performed this case-control study, including 459 breast cancer (BC) patients and 549 healthy controls from Northwest China, to evaluate the associations between two common MT2A polymorphisms (rs10636 and rs28366003) and BC risk. The MT2A polymorphisms were genotyped via Sequenom MassARRAY. The individuals with the rs28366003 A/G, A/G-G/G genotypes underwent a higher risk of BC (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1504a53c00a08be1d5d7cb21c980eda https://doi.org/10.18632/aging.101177 Zobrazit plný text záznamu