Approaches for the synthesis of functionalized cryptophycins

Autor:	Markus Nahrwold, Christine Weiss, Tobias Bogner, Norbert Sewald, Benedikt Sammet
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Molecular Structure Chemistry Stereochemistry Carboxylic acid Organic Chemistry Stereoisomerism Chemical synthesis Cyclic peptide chemistry.chemical_compound Cryptophycin Depsipeptides Staudinger reaction Azide Protecting group Cryptophycins
Zdroj:	The Journal of organic chemistry. 75(20)
ISSN:	1520-6904
Popis:	The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry and enable a very convenient synthesis of cryptophycin-52 and unit D cryptophycin analogues containing an ester or a free carboxylic acid for bioconjugations. Both new cryptophycin derivatives show high biological activity in cytotoxicity assays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14c246788e173ee3d82b9b1cc344006 https://pubmed.ncbi.nlm.nih.gov/20857920 Zobrazit plný text záznamu