Outdoor light at night and risk of endometrial cancer in the NIH-AARP diet and health study

Autor: Danielle N. Medgyesi, Britton Trabert, Jared A. Fisher, Qian Xiao, Peter James, Alexandra J. White, Jessica M. Madrigal, Rena R. Jones
Rok vydání: 2022
Předmět:
Zdroj: Cancer Causes Control
ISSN: 1573-7225
Popis: PURPOSE. Outdoor light at night (LAN) can result in circadian disruption and hormone dysregulation and is a suspected risk factor for some cancers. Our study is the first to evaluate the association between LAN and risk of endometrial cancer, a malignancy with known relationship to circulating estrogen levels. METHODS. We linked enrollment addresses (1996) for 97,677 postmenopausal women in the prospective NIH-AARP cohort to satellite imagery of nighttime radiance to estimate LAN exposure. Multivariable Cox models estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for LAN quintiles and incident endometrial cancer overall (1,669 cases) and endometrioid adenocarcinomas (991 cases) through follow-up (2011). We tested for interaction with established endometrial cancer risk factors. RESULTS. We observed no association for endometrial cancer overall (HR(Q1vsQ5)=0.92; 95%CI=0.78–1.08; ptrend=0.67) or endometrioid adenocarcinoma (HR(Q1vsQ5)=1.01; 95%CI=0.82–1.24; ptrend=0.36). Although body mass index and menopause hormone therapy were both associated with risk, there was no evidence of interaction with LAN (pinteractions=0.52 and 0.50, respectively). CONCLUSION. Our study did not find an association between outdoor LAN and endometrial cancer risk, but was limited by inability to account for individual-level exposure determinants. Future studies should consider approaches to improve characterization of personal exposures to light.
Databáze: OpenAIRE
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