Extranodal NK/T-cell lymphoma, nasal type presenting as primary intestinal lymphoma vs intestinal T-cell lymphoma: A borderline diagnostic category in the revised WHO classification
| Autor: | Eugenio Palomino, Brady E Beltran, Julio C. Chavez, Eduardo M. Sotomayor, Jorge J. Castillo, Mario L. Marques-Piubelli, M. Pilar Quiñones, Roberto N. Miranda, Johnny Morales, Wilder Ramos, Esther Cotrina |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Abdominal pain business.industry Perforation (oil well) Peripheral T-cell lymphoma Peritonitis medicine.disease Extranodal NK/T-cell lymphoma nasal type NK/T-cell Pathology and Forensic Medicine Lymphoma Intestinal lymphoma EBV hemic and lymphatic diseases RB1-214 Medicine T-cell lymphoma Differential diagnosis medicine.symptom business |
| Zdroj: | Human Pathology: Case Reports, Vol 25, Iss, Pp 200534-(2021) |
| ISSN: | 2214-3300 |
| DOI: | 10.1016/j.ehpc.2021.200534 |
| Popis: | Extranodal NK/T-cell lymphoma, nasal type, is an unusual Epstein-Barr Virus (EBV)-related lymphoma that carries a poor prognosis. Most cases affect upper aerodigestive tract, and secondarily may extend to skin, lungs, testis, and other sites. Extranodal NK/T-cell lymphoma, nasal type, presenting primarily as intestinal lymphoma is rare, and not recognized as a distinct entity and neither is considered as a special subtype of intestinal lymphoma of T-cell lineage. Here, we describe a 36-year-woman who presented with abdominal pain and acute-onset diarrhea. Her clinical course was complicated by intestinal perforation and peritonitis. She died one month later of sepsis. Pathologic examination revealed extranodal NK/T-cell lymphoma, nasal type, confined to the intestine. Immunophenotypically, the neoplastic cells expressed CD3 and Granzyme B, and were positive for EBV-encoded RNA (EBER) by in situ hybridization. From the practical point of view, we highlight the clinical, pathologic and immunophenotypic features that can be useful in the differential diagnosis from other intestinal lymphomas of T-cell lineage. |
| Databáze: | OpenAIRE |
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