Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population
| Autor: | Stephan J. L. Bakker, Parisa Aghagolzadeh, Martin H. de Borst, Marc G. Vervloet, Jan-Luuk Hillebrands, Harry van Goor, Ron T. Gansevoort, Matthias Bachtler, Anne-Roos S. Frenay, Coby Eelderink, Andreas Pasch, Charlotte A Te Velde-Keyzer, Peter R van Dijk, Emma A. Vermeulen |
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| Přispěvatelé: | Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Population 030232 urology & nephrology Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Cause of Death medicine Humans Prospective Studies education Vascular Calcification Vascular calcification Aged Proportional Hazards Models education.field_of_study business.industry Middle Aged medicine.disease Cardiovascular Diseases Cardiology Kidney Failure Chronic Female Cardiology and Cardiovascular Medicine business All cause mortality Calcification |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology, 40(8), 1942-1951. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/ATVBAHA.120.314187 |
| Popis: | Objective: Vascular calcification contributes to the cause of cardiovascular disease. The calciprotein particle maturation time (T 50 ) in serum, a measure of calcification propensity, has been linked with adverse outcomes in patients with chronic kidney disease, but its role in the general population is unclear. We investigated whether serum T 50 is associated with cardiovascular mortality in a large general population-based cohort. Approach and Results: The relationship between serum T 50 and cardiovascular mortality was studied in 6231 participants of the PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort. All-cause mortality was the secondary outcome. Mean (±SD) age was 53±12 years, 50% were male, and mean serum T 50 was 329±58 minutes. A shorter serum T 50 is indicative of a higher calcification propensity. Serum T 50 was inversely associated with circulating phosphate, age, estimated glomerular filtration rate, and alcohol consumption, whereas plasma magnesium was positively associated with serum T 50 ( P R 2 =0.281). During median (interquartile range) follow-up for 8.3 (7.8–8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T 50 was independently associated with a higher risk of cardiovascular mortality (fully adjusted hazard ratio [95% CI], 1.22 [1.04–1.36], P =0.021). This association was modified by diabetes mellitus; stratified analysis indicated a more pronounced association in individuals with diabetes mellitus. Conclusions: Serum T 50 is independently associated with an increased risk of cardiovascular mortality in the general population and thus may be an early and potentially modifiable risk marker for cardiovascular mortality. |
| Databáze: | OpenAIRE |
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