Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease
| Autor: | X, Yang, T, Ahmad, F, Gogus, D, Verity, G R, Wallace, W, Madanat, C A, Kanawati, M R, Stanford, F, Fortune, D P, Jewell, S E, Marshall |
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| Rok vydání: | 2004 |
| Předmět: |
Chemokine
Genotype Receptors CCR5 Turkey Immunology Behcet's disease Disease White People Pathogenesis Cohort Studies Chemokine receptor Gene Frequency Genetics medicine Ccr5 δ32 Humans Genetic Predisposition to Disease Allele frequency Alleles Polymorphism Genetic biology Behcet Syndrome Genetic Variation medicine.disease United Kingdom Arabs HLA-B Antigens biology.protein HLA-B51 Antigen Receptors Chemokine CC chemokine receptors |
| Zdroj: | European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 31(1) |
| ISSN: | 0960-7420 |
| Popis: | Summary Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Δ32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behcet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51. |
| Databáze: | OpenAIRE |
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