Effects of Ethaverine Hydrochloride on the Walking Tolerance of Patients with Intermittent Claudication
| Autor: | Frieda S. Trainor, David D. Michie, James M. Chubb, Raymond E. Phillips, Stephen R. Zellner, Leo Hogan |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Brachial Artery Blood Pressure 030204 cardiovascular system & hematology Placebo Random Allocation 03 medical and health sciences 0302 clinical medicine Double-Blind Method Papaverine medicine.artery Humans Medicine Treadmill Brachial artery Clinical Trials as Topic business.industry Intermittent Claudication Middle Aged Intermittent claudication Surgery medicine.anatomical_structure Blood pressure Anesthesia Exercise Test Female Ankle medicine.symptom Cardiology and Cardiovascular Medicine business Claudication 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Angiology. 37:343-351 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331978603700502 |
| Popis: | The effect of ethaverine hydrochloride on excercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-con trolled study conducted at three sites. Forty-five patients with symptoms of oc clusive arterial insufficiency of the lower extremities were randomly assigned to receive ethaverine 200 mg or placebo four times daily. The patients were evalu ated biweekly for 12 weeks with treadmill claudication tests, patient and investi gator assessments of symptom severity, and reports of adverse reactions. Doppler ankle/brachial pressure ratios were recorded for 26 patients. Walking tolerance improved for patients in both groups during the course of the study. Increases in distance-to-claudication were significantly greater for patients receiving ethaverine after 6, 8, 10, and 12 weeks of therapy. Ankle/ brachial pressure index after exercise was unchanged in both groups. Incidence of adverse reactions was similar for the two groups. Although patients were generally unaware of any improvement in symptoms, the investigators judged significant relief of claudication among those receiving ethaverine compared to those receiving placebo. It was concluded that ethaverine safely increased dis tance-to-claudication in patients with intermittent claudication. |
| Databáze: | OpenAIRE |
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