Toxicological evaluations of some brominated biphenyls
| Autor: | R. S. Waritz, C. S. Hornberger, F. D. Griffith, F. . Tayfun, Sherman H, Ki P. Lee, R. Culik, L. Dashiell, M. M. Faunce, J. G. Aftosmis |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Skin Absorption Guinea Pigs Polybrominated Biphenyls Physiology Human skin Biology Dermatitis Contact Eye Quail Octabromobiphenyl Toxicology Guinea pig Rat fetus Fetus medicine Animals Humans Sensitization Skin Biphenyl Compounds Body Weight Public Health Environmental and Occupational Health Abnormalities Drug-Induced Environmental Exposure Organ Size Acute toxicity Diet Rats medicine.anatomical_structure Skin irritation Liver Bioaccumulation Female Rabbits Hepatomegaly |
| Zdroj: | American Industrial Hygiene Association journal. 38(7) |
| ISSN: | 0002-8894 |
| Popis: | Extensive toxicological studies were carried out to define the probable hazard of octabromobiphenyl (OBB) to workers, users, and the environment. OBB had low acute toxicity in mammals and birds by various routes of administration. It was essentially non-irritating to rabbit eyes, non-irritating to human skin and caused only mild skin irritation and no sensitization in the guinea pig. OBB caused equivocal effects in the rat fetus. OBB was stored in the body fat of rats and caused liver enlargement at high single doses or low repeated doses. The studies indicate probable low safety factors in application and use and probable bioaccumulation. Hexabromobiphenyl (HBB) was more acutely toxic than OBB by skin absorption in the rabbit and caused liver enlargement at lower single doses. |
| Databáze: | OpenAIRE |
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