Wash-in rate on the basis of dynamic contrast-enhanced MRI: usefulness for prostate cancer detection and localization
| Autor: | Seong Sook Hong, Jeong Kon Kim, Kyoung-Sik Cho, Hanjong Ahn, Choung-Soo Kim, Seong Ho Park, Young Jun Choi |
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| Rok vydání: | 2005 |
| Předmět: |
Gadolinium DTPA
Male medicine.medical_specialty Metabolic Clearance Rate Contrast Media Indicator Dilution Techniques Models Biological Sensitivity and Specificity Prostate cancer Text mining Parametric imaging Image Interpretation Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Tissue Distribution Aged medicine.diagnostic_test business.industry Cancer Prostatic Neoplasms Reproducibility of Results Magnetic resonance imaging Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Wash in rate Organ Specificity Dynamic contrast-enhanced MRI Radiology business Nuclear medicine Algorithms Endorectal coil |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 22(5) |
| ISSN: | 1053-1807 |
| Popis: | Purpose To evaluate the usefulness of the wash-in rate based on dynamic contrast-enhanced (DCE) MRI for the detection and localization of prostate cancer. Materials and Methods In 53 patients, the wash-in rate was measured in the cancer area and in three normal areas (the peripheral zone, inner portion of the transitional zone, and outer portion of the transitional zone). On the basis of these data, parametric imaging was generated and then its accuracy for cancer detection and location was evaluated compared to that of T2-weighted imaging without the use of an endorectal coil. For that purpose the entire prostate was divided into 18 segments. Results The wash-in rate value was greater in cancer tissue (9.2/second) than in three normal tissues (3.3/second, 6.7/second, and 3.2/second, respectively; P < 0.001). The sensitivity and specificity were greater on parametric imaging of the wash-in rate compared to T2-weighted imaging in the entire prostate (96% and 82% vs. 65% and 60%, respectively) and the peripheral zone (96% and 97% vs. 75% and 53%; P < 0.05). In the transitional zone, the sensitivity was greater on parametric imaging (96%) than on T2-weighted imaging (45%; P = 0.016), but the specificity was similar (51% vs. 73%; P = 0.102). Conclusion The wash-in rate based on DCE-MRI is a useful parameter for prostate cancer detection and localization. J. Magn. Reson. Imaging 2005. © 2005 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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