Association Between the Levels of Circulating Adhesion Molecules and Biopterins in Type-2 Diabetic Normotensive Patients Adhesion Molecules and Biopterins
| Autor: | Alberto Francisco Rubio-Guerra, Leonardo Del Valle-Mondragón, José Juan Lozano-Nuevo, Hilda Vargas-Robles, Bruno Alfonso Escalante-Acosta |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Vascular Cell Adhesion Molecule-1 Blood Pressure Enzyme-Linked Immunosorbent Assay Inflammation High-performance liquid chromatography Internal medicine medicine Humans Immunology and Allergy Endothelial dysfunction Aged chemistry.chemical_classification biology Chemistry Cell adhesion molecule Tetrahydrobiopterin Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Biopterin Nitric oxide synthase Endocrinology Enzyme Diabetes Mellitus Type 2 Solubility biology.protein Female Endothelium Vascular Analysis of variance medicine.symptom E-Selectin medicine.drug |
| Zdroj: | Endocrine, Metabolic & Immune Disorders-Drug Targets. 12:243-246 |
| ISSN: | 1871-5303 |
| Popis: | Endothelial dysfunction is a common feature in type-2 diabetic patients and is associated with inflammation, increased levels of circulating soluble adhesion molecules and atherosclerosis. Insufficiency of tetrahydrobiopterin leads to uncoupling of the nitric oxide synthase enzyme an endothelial dysfunction. The aim of this study: was to evaluate if there is a relationship between the levels of circulating soluble adhesion molecules and the levels of biopterins in normotensive type-2 diabetic patients. Methods: We studied 30 normotensive type-2 diabetic patients in whom VCAM-1, ICAM-1 and E-selectin were measured by ELISA. Additionally, Biopterins were measured by reverse phase high performance liquid chromatography with fluorescence detection. The levels of circulating adhesion molecules and biopterins were correlated using the Spearman correlation coefficient test. Statistical analysis was performed with ANOVA. Results: We did not find any relationship between absolute values of biopterins and soluble adhesion molecules. However, we observed significant inverse correlations between the BH4/BH2 ratio and VCAM-1 (r= -0.65, p |
| Databáze: | OpenAIRE |
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