Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Exposure-Response Analysis of 14 Case-Control Studies

Autor: Ge, Calvin, Peters, Susan, Olsson, Ann, Portengen, Lützen, Schüz, Joachim, Almansa, Josué, Ahrens, Wolfgang, Bencko, Vladimir, Benhamou, Simone, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Caporaso, Neil, Consonni, Dario, Demers, Paul, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Janout, Vladimir, Jöckel, Karl Heinz, Karrasch, Stefan, Teresa Landi, Maria, Lissowska, Jolanta, Luce, Danièle, Mates, Dana, McLaughlin, John, Merletti, Franco, Mirabelli, Dario, Pándics, Tamás, Parent, Marie Élise, Plato, Nils, Pohlabeln, Hermann, Richiardi, Lorenzo, Siemiatycki, Jack, Świątkowska, Beata, Tardón, Adonina, Wichmann, Heinz Erich, Zaridze, David, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2
Přispěvatelé: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment [Bilthoven] (RIVM), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Toronto, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Azienda Sanitaria Locale [ROMA] (ASL), Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Faculty of Medicine, Palacky University Olomouc, Institute for Medical Informatics, Biometry, and Epidemiology, Universität Duisburg-Essen [Essen], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Public Health, Cancer Care Ontario, Occupational Cancer Research Centre, Cancer Epidemiology Unit, Université de Turin, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Bremen Institute for Prevention Research and Social Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), King‘s College London, Institute of Carcinogenesis, Russian Academy of Medical Sciences, Masaryk Memorial Cancer Institute (MMCI), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: American Journal of Respiratory and Critical Care Medicine, 202(3), 402. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 202 (3), pp.402-411. ⟨10.1164/rccm.201911-2101OC⟩
American Journal of Respiratory and Critical Care Medicine, 202(3), 402-411. AMER THORACIC SOC
American Journal of Respiratory and Critical Care Medicine, 2020, 202 (3), pp.402-411. ⟨10.1164/rccm.201911-2101OC⟩
Am. J. Respir. Crit. Care Med. 202, 402-411 (2020)
ISSN: 1073-449X
1535-4970
DOI: 10.1164/rccm.201911-2101OC⟩
Popis: Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes.Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations.Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men.Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 mu g/m(3) were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined.Conclusions: We observed a consistent exposure-response relationship betweenECexposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.
Databáze: OpenAIRE
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