Unusually high levels of serum p53 antibody in recurrent gastric cancer
| Autor: | Takeshi Nagayasu, Yukie Kinoshita, Keiko Hamasaki, Shigekazu Hidaka, Kouki Wakata, Masaki Kunizaki |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Antibodies Neoplasm medicine.medical_treatment Gastroenterology 03 medical and health sciences 0302 clinical medicine Surgical oncology Gastrectomy Stomach Neoplasms Internal medicine medicine Biomarkers Tumor Humans Tumor marker Aged biology business.industry Cancer General Medicine Hepatology medicine.disease Small intestine Ileal Neoplasms Titer medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology biology.protein 030211 gastroenterology & hepatology Female Antibody Tumor Suppressor Protein p53 business Carcinoma Signet Ring Cell |
| Zdroj: | Clinical journal of gastroenterology. 10(6) |
| ISSN: | 1865-7265 |
| Popis: | Serum tumor markers in patients with cancer assist with establishing diagnosis, estimating prognosis, monitoring treatment, and detecting tumor recurrence. Changes in the p53 tumor suppressor gene are the most common genetic abnormalities in many different human malignancies. Several studies have demonstrated that serum p53 antibodies (S-p53Ab) comprise an early marker of malignant disease, a marker for treatment effects and a prognostic factor for patients with several types of tumors. We recently reported that S-p53Ab is useful for patients with gastric cancer. We describe a rare situation in which unusually high serum p53 antibodies helped to detect recurrent gastric cancer in the small intestine after gastrectomy. Further studies are required to gain a more precise understanding of the clinical impact of S-p53Ab titer monitoring in gastric cancer. |
| Databáze: | OpenAIRE |
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