Use of cyclodextrins in capillary zone electrophoresis for the separation of optical isomers: Resolution of racemic tryptophan derivatives
| Autor: | Salvatore Fanali, L. Ossicini, Annalisa Nardi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Ester derivatives Chromatography Cyclodextrin Resolution (mass spectrometry) Organic Chemistry Tryptophan technology industry and agriculture Electrolyte Oligosaccharide Catalysis Analytical Chemistry carbohydrates (lipids) Capillary electrophoresis chemistry Drug Discovery polycyclic compounds lipids (amino acids peptides and proteins) Enantiomer Spectroscopy |
| Zdroj: | Chirality (N.Y., N.Y. Print) 4 (1992): 56–61. doi:10.1002/chir.530040112 info:cnr-pdr/source/autori:NARDI A, OSSICINI L, FANALI S/titolo:Use of cyclodextrins in capillary zone electrophoresis for the separation of optical isomers: Resolution of racemic tryptophan derivatives/doi:10.1002%2Fchir.530040112/rivista:Chirality (N.Y., N.Y. Print)/anno:1992/pagina_da:56/pagina_a:61/intervallo_pagine:56–61/volume:4 |
| DOI: | 10.1002/chir.530040112 |
| Popis: | In this study capillary zone electrophoresis has been used for the separation of racemic tryptophan derivatives in their enantiomers. The effect of cyclodextrins with different shape, added to the background electrolyte, on the migration time of 10 compounds, including methyl tryptophan, hydroxy tryptophan, and tryptophan ester derivatives, has been studied. Furthermore, the effect of cyclodextrins with different shape and that of the composition of the background electrolyte on the enantiomer resolution are discussed. Among different cyclodextrins used α-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin were found to possess the best complexing capacity and thus the resolution power toward analysed compounds. |
| Databáze: | OpenAIRE |
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