[Correction of lipid peroxidation and antioxidant system disorders by bioflavonoids during modeling of cholesterol atherosclerosis in rabbits]
| Autor: | Shysh A, Pashevin Do, Dosenko VIe, O O Moĭbenko |
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| Předmět: |
chemistry.chemical_classification
Antioxidant biology Myocardial tissue Physiology Cholesterol medicine.medical_treatment Pharmacology Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Enzyme chemistry Biochemistry Catalase biology.protein medicine lipids (amino acids peptides and proteins) Quercetin |
| Zdroj: | Europe PubMed Central |
| Popis: | We have studied the influence of bioflavonoids (quercetin, corvitin) on lipid peroxidation and antioxidant enzymes in the modeling of cholesterol atherosclerosis in rabbits. It has been shown that simultaneous administration of the quercetin derivative corvitin suppressed lipid peroxidation. We showed that under hypercholesterolemia, the concentration of malone dialdehyde in myocardial tissue in rabbits is significantly increased, while administration of bioflavonoids decreased the concentration of malone dialdehyde by 38.3%. Furthermore, corvitin caused activating effects on antioxidant enzymes superoxide dismutase and catalase in cardiac tissue. Our data suggest that bioflavonoids are able to suppress lipid peroxidation and prevent the decrease ofantioxidant enzymes activity in rabbits with cholesterol-rich diet induced atherosclerosis. |
| Databáze: | OpenAIRE |
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