The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population
| Autor: | M. P. Kostinov, А. D. Protasov, А. V. Zhetkov, M. L. Shteyner, Yu. V. Tezikov, I. S. Lipatov |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class chronic obstructive pulmonary disease Diseases of the respiratory system Bronchodilator Internal medicine pneumococcal infection pneumovax-23 medicine Respiratory function Medical history prevenar-13 COPD RC705-779 business.industry General Medicine vaccination medicine.disease conjugated polysaccharide vaccine polysaccharide vaccine Vaccination Regimen microbiological effect Salbutamol Sputum medicine.symptom business medicine.drug |
| Zdroj: | Tuberkulez i Bolezni Lëgkih, Vol 99, Iss 7, Pp 7-17 (2021) |
| ISSN: | 2542-1506 2075-1230 |
| Popis: | The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumococcal vaccination groups, they were examined and followed up for 4 years; 112 patients completed the study complying with the protocol. Detail medical history of all subjects was collected. To verify the diagnosis of COPD, all subjects underwent external respiratory function test and bronchodilator test (salbutamol, 400 μg) according to the standard method. The classic microbiological assessment was used in this study. The clinical effectiveness of vaccination was assessed. Statistical processing of the results was performed using StatPlus Pro 6.2.0.0 software (license number 2883).Results. Сonsecutive vaccination with pneumococcal conjugate and polysaccharide vaccines leads to decreased isolation rate of pneuniococcus from the sputum of CODP patients. The frequency of exacerbations, the need for antibiotic chemotherapy and hospitalizations also goes down. |
| Databáze: | OpenAIRE |
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