The role of vitamin D in adipogenesis
| Autor: | Olivia Wright, Clare F. Dix, Johanna L Barcley |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Medicine (miscellaneous) Adipose tissue chemistry.chemical_element 030209 endocrinology & metabolism Cochrane Library Calcium vitamin D deficiency Cell Line Secosteroid Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Animals Humans Obesity Vitamin D Adipogenesis Nutrition and Dietetics business.industry medicine.disease 030104 developmental biology Endocrinology chemistry business |
| Zdroj: | Nutrition Reviews. 76:47-59 |
| ISSN: | 1753-4887 0029-6643 |
| Popis: | Vitamin D, a secosteroid predominately obtained by endogenous production, has in recent years been linked to obesity and its comorbidities. The purpose of this review is to draw conclusions from animal and human studies on the effects of vitamin D on adipogenesis to identify the molecular links between vitamin D and obesity. The information presented herein was obtained from 4 databases (PubMed, CINAHL, Cochrane Library, Scopus) using predefined search terms, as well as research literature and other reviews. The effects of vitamin D on adipogenesis have been researched in several animal models, and the majority of these studies suggest vitamin D plays an inhibitory role in adipogenesis. Studies into vitamin D status and obesity in humans are limited, with the majority being observational epidemiological studies that provide no conclusions on cause and effect or clear links on the molecular mechanisms. The few cell culture and supplementation studies that have investigated adipogenesis in human cells indicate that, in contrast to findings from rodent studies, vitamin D is proadipogenic. There is insufficient evidence to determine whether 1) vitamin D deficiency is associated with a lean or obese phenotype, 2) vitamin D deficiency is a consequence of obesity, or (3) the effects of vitamin D on fat tissue are due to interactions with calcium. |
| Databáze: | OpenAIRE |
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