Evaluation of primary lung carcinoma using technetium 99m-hexamethylpropylene amine oxime: preliminary clinical experience
| Autor: | Sadayuki Sakuma, Itoh K, Motoo Oshima, Shunji Okae, Masanori Tadokoro, Yukihiro Kodama |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms chemistry.chemical_element Adenocarcinoma Technetium Technetium Tc 99m Exametazime Carcinoma Non-Small-Cell Lung Oximes medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Aged Tomography Emission-Computed Single-Photon Lung business.industry Large cell Organotechnetium Compounds General Medicine medicine.disease medicine.anatomical_structure Cerebral blood flow chemistry Carcinoma Squamous Cell Female business Technetium-99m Perfusion |
| Zdroj: | European Journal of Nuclear Medicine. 16:859-864 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf01280252 |
| Popis: | 99mTc-labelled hexamethylpropylene amine oxime (HMPAO) is a lipophilic compound with a neutral charge which reflects tumor blood flow and has been previously investigated to estimate brain blood flow. In this study, we attempted to use 99mTc-HMPAO for the evaluation of 18 patients with histologically proven primary lung carcinoma. The eight surgical specimens revealed that viable carcinoma cells were present when the 99mTc-HMPAO accumulated in the tumor, however, extensive tumor necrosis was observed when defective or ring like uptake was seen in the tumor. Qualitative study revealed that when perfusion defects were observed corresponding to the tumor, the possibility of squamous cell carcinoma or large cell carcinoma was high instead of adenocarcinoma. Quantitative analysis revealed that the uptake ratio was statistically different between adenocarcinoma (1.6 +/- 0.1) and squamous cell carcinoma (1.2 +/- 0.4) (P less than 0.05), between squamous cell carcinoma and large cell carcinoma (0.9 +/- 0.1) (P less than 0.05), and also between adenocarcinoma and large cell carcinoma (P less than 0.01). In conclusion, 99mTc-HMPAO may be useful for the evaluation of patients with primary lung carcinoma. |
| Databáze: | OpenAIRE |
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