Progression of a Nelson's adenoma to pituitary carcinoma; a case report and review of the literature

Autor: Anthony G. H. Smals, Pieter Wesseling, A. R. M. M. Hermus, Albert A.J. Verhofstad, G. F. F. M. Pieters, S. A. G. Kemink
Rok vydání: 1999
Předmět:
Adult
Pathology
medicine.medical_specialty
Adenoma
Endocrinology
Diabetes and Metabolism
Thyrotropin
Pathofysiologie van Hersenen en Gedrag
Adrenocorticotropic hormone
Pathophysiology of Brain and Behaviour
Pituitary neoplasm
Nelson Syndrome
Cushing syndrome
Endocrinology
Fatal Outcome
Pathofysiologie en therapie van het syndroom van Cushing en van andere stoornissen in de cortisol-huishouding
Adrenocorticotropic Hormone
Carcinoma
Medicine
Humans
Neoplasm Invasiveness
Pituitary Neoplasms
Pathophysiology and therapy of Cushing's syndrome and other disturbances in secretion or metabolism of cortisol
Tumor pathology
Neoplasm Metastasis
Cushing Syndrome
business.industry
Adrenalectomy
Tumor pathologie
medicine.disease
Cell Transformation
Neoplastic
Pituitary carcinoma
Adenocarcinoma
Female
business
Zdroj: Journal of Endocrinological Investigation, 22, pp. 70-75
Journal of Endocrinological Investigation, 22, 70-75
ISSN: 0391-4097
1720-8386
Popis: A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.
Databáze: OpenAIRE
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