Lack of ultraviolet mutagenesis in radiation-resistant bacteria
| Autor: | Philip R. Tempest, B. E. B. Moseley |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Methylnitronitrosoguanidine
Mutation Bacteria biology Ultraviolet Rays DNA damage Mutagenesis Mutant Pseudomonas Drug Resistance Microbial Deinococcus radiodurans General Medicine biology.organism_classification medicine.disease_cause Radiation Tolerance Microbiology chemistry.chemical_compound Nitrosomethylurethane Species Specificity chemistry medicine Rifampin |
| Zdroj: | Mutation Research Letters. 104:275-280 |
| ISSN: | 0165-7992 |
| Popis: | Ultraviolet (UV) radiation did not induce rifampicin-resistant mutants in populations of the taxonomically-related radiation-resistant bacteria Deinococcus radiodurans, D. radiopugnans, D. radiophilus and D. proteolyticus, although such mutants arose spontaneously at a low frequency and at a high frequency after treatment of cultures with N-nitroso compounds. The radiation-resistant bacteria Arthrobacter radiotolerans and P-30-A were also UV-immutable whereas the more radiation-sensitive Pseudomonas radiora was UV-mutable. We conclude that the radiation-resistant bacteria repair UV-induced DNA damage accurately and lack an error-prone pathway for the repair of such damage. |
| Databáze: | OpenAIRE |
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