A population-based European cohort study of persistence in newly diagnosed hypertensive patients
| Autor: | J Hasford, A Mimran, W R Simons |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic beta-Antagonists Tetrazoles Angiotensin-Converting Enzyme Inhibitors Angiotensin II receptor antagonist Pharmacology Losartan Persistence (computer science) Cohort Studies Angiotensin Receptor Antagonists Irbesartan Internal medicine Internal Medicine Humans Medicine Treatment Failure Antihypertensive Agents Aged Receptors Angiotensin business.industry Medical record Biphenyl Compounds Middle Aged Calcium Channel Blockers Europe Blood pressure Tolerability Hypertension Retreatment Female business Cohort study medicine.drug |
| Zdroj: | Journal of Human Hypertension. 16:569-575 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1001451 |
| Popis: | This study assessed the percentage of patients after 1 year who persisted on initially prescribed antihypertensive therapy. Medical records of 2416 patients with newly diagnosed hypertension who were prescribed initial antihypertensive monotherapy by general practitioners in Germany, France, and the United Kingdom were evaluated. Comparisons were made among the angiotensin II receptor antagonist (AIIRA) irbesartan, all other antihypertensive classes (including AIIRAs other than irbesartan), and the AIIRA losartan. Patients initiated on the AIIRA irbesartan scored highest with a persistence rate of 60.8%, followed by patients who received all other AIIRA agents with a persistence rate of 51.3%. Angiotensin-converting enzyme inhibitors, calcium channel blockers, beta-blockers, and losartan were associated with comparable persistence rates, between 42.0% and 49.7%. Patients who received diuretics scored lowest with a persistence rate of 34.4%. Persistence has emerged as an essential factor for blood pressure control. Prescribing an antihypertensive agent that provides a favourable efficacy and tolerability profile may provide greater persistence with therapy and hence a higher level of blood pressure control. |
| Databáze: | OpenAIRE |
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