Homology Modeling Of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights Into Isoenzyme-Specific Differences Using Molecular Docking Simulatons
| Autor: | Eren Gokcen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Nicotinamide
010405 organic chemistry Chemistry Stereochemistry Pharmaceutical Science 01 natural sciences Isozyme 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Biochemistry Drug Discovery Molecular Medicine Homology modeling Nicotinic acid mononucleotide adenylyltransferase |
| Popis: | Background: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that plays crucial roles in energy metabolism, DNA repair and cell death. Due to the high proliferation rate and the high energy necessity in cancer cells, NAD biosynthesis and salvage is required. Owing to the NAD importance in cancer cells, NAD salvage/recycling enzymes are targets for drug discovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|