Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats
| Autor: | Gerhard Rechkemmer, Bernhard Watzl, Monika Roller |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty Synbiotics Neutrophils medicine.medical_treatment Medicine (miscellaneous) Oligosaccharides CD8-Positive T-Lymphocytes Monocytes law.invention Microbiology Cecum Probiotic Peyer's Patches Immune system Lactobacillus rhamnosus Phagocytosis law Internal medicine medicine Animals Bifidobacterium Respiratory Burst Nutrition and Dietetics biology Prebiotic Probiotics Inulin biology.organism_classification Rats Inbred F344 Bifidobacterium animalis Diet Interleukin-10 Rats Intestines Killer Cells Natural Lactobacillus Endocrinology medicine.anatomical_structure Immunoglobulin A Secretory |
| Zdroj: | The Journal of nutrition. 134(1) |
| ISSN: | 0022-3166 |
| Popis: | Probiotics (PRO) modulate systemic immunity in animals and humans. In contrast, the effects of prebiotics (PRE) on systemic and intestinal immunity have not been investigated. Whether the combined application of PRO and PRE [synbiotics (SYN)] has synergistic or additive effects is presently unknown. Therefore, PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin enriched with oligofructose), and SYN (combination of PRO and PRE) were fed to F344 rats for 4 wk as supplements to a high fat diet. Functions of immune cells isolated from peripheral blood mononuclear cells (PBMC), spleen, mesenterial lymph nodes and Peyer's patches (PP) were investigated. The SYN supplement increased secretory immunoglobulin A (sIgA) production in the ileum compared with controls fed the high fat diet alone (P |
| Databáze: | OpenAIRE |
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