Left Atrial Volumes and Strain in Healthy Children Measured by Three-Dimensional Echocardiography: Normal Values and Maturational Changes
| Autor: | Joseph D. Kuebler, David N. Williams, Tal Geva, David M. Harrild, Douglas P. Perrin, Gerald R. Marx, Steven D. Colan, Divya Shakti, David W. Brown, Sunil J. Ghelani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty Heart disease Adolescent Intraclass correlation Cardiac Volume Diastole Echocardiography Three-Dimensional 030204 cardiovascular system & hematology Standard score 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Interquartile range Reference Values Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Heart Atria Child Retrospective Studies Body surface area Ejection fraction business.industry Infant Newborn Infant Stroke Volume medicine.disease medicine.anatomical_structure Cross-Sectional Studies Ventricle Child Preschool Cardiology Atrial Function Left Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 31(2) |
| ISSN: | 1097-6795 |
| Popis: | Background Assessment of left atrial (LA) size and function is important in a number of pediatric cardiac conditions including those affecting the diastolic performance of the left ventricle. Measurements of LA volume and strain by two-dimensional echocardiography rely upon inaccurate geometric assumptions and are hampered by out-of-plane motion. The objective of this study was to characterize LA volumes and strain by three-dimensional echocardiography in healthy children. Methods LA volumes and strain were retrospectively measured by three-dimensional echocardiography in healthy children with no known structural or functional heart disease using a commercial speckle-tracking package applied to the LA to compute maximum volume ( V max ), minimum volume ( V min ), ejection volume (LAEV), ejection fraction (LAEF), and the following components of global strain: 3D principal (3DS), longitudinal (GLS), and circumferential (GCS). Results The study population included 196 normal subjects (median age, 12 years; range, 4 days to 20.9 years). V max , V min , and LAEV increased with age and body surface area. Significant age-related declines were present in all measured functional indices including LAEF, 3DS, GLS, and GCS. Analysis of a subset of 50 subjects showed excellent agreement between V max derived by three-dimensional and two-dimensional biplane area-length method. Regression equations with standard deviations were generated to enable calculation of Z scores. Conclusions LA volume and functional indices can be reliably calculated using a commercial three-dimensional analysis software. All components of LA strain decline modestly with age. Normative data generated in this study have the potential to greatly enhance the utility of three-dimensional echocardiography-derived measurements in a wide range of cardiac pathologies. |
| Databáze: | OpenAIRE |
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