Prophylactic antibiotic treatment in severe acute ischemic stroke: the Antimicrobial chemopRrophylaxis for Ischemic STrokE In MaceDonIa–Thrace Study (ARISTEIDIS)
| Autor: | Haralampos J. Milionis, D. Agapakis, Apostolos I. Hatzitolios, George Ntaios, Konstantinos Tziomalos, Nikolaos Papanas, Christos Savopoulos, Andreas Xanthis, Efstratios Maltezos, Spiros Miyakis |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Internal Medicine medicine Humans Antibiotic prophylaxis Aged Aged 80 and over Cefuroxime business.industry Incidence (epidemiology) Pneumonia Antibiotic Prophylaxis Antimicrobial medicine.disease Confidence interval Anti-Bacterial Agents Surgery Patient Outcome Assessment Stroke Relative risk Urinary Tract Infections Emergency Medicine Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Internal and Emergency Medicine. 11:953-958 |
| ISSN: | 1970-9366 1828-0447 |
| Popis: | Infections represent a leading cause of mortality in patients with acute ischemic stroke, but it is unclear whether prophylactic antibiotic treatment improves the outcome. We aimed to evaluate the effects of this treatment on infection incidence and short-term mortality. This was a pragmatic, prospective multicenter real-world analysis of previously independent consecutive patients with acute ischemic stroke who were >18 years, and who had at admission National Institutes of Health Stroke Scale (NIHSS) >11. Patients with infection at admission or during the preceding month, with axillary temperature at admission >37 °C, with chronic inflammatory diseases or under treatment with corticosteroids were excluded from the study. Among 110 patients (44.5 % males, 80.2 ± 6.8 years), 31 (28.2 %) received prophylactic antibiotic treatment, mostly cefuroxime (n = 21). Prophylactic antibiotic treatment was administered to 51.4 % of patients who developed infection, and to 16.4 % of patients who did not (p |
| Databáze: | OpenAIRE |
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