Clinical Scoring System for Vulvar Lichen Sclerosus
| Autor: | Andreas R. Günthert, Esther Amann, Kathleen Duclos, Boriana G. Jahns, Michael D. Mueller, Andreas Limacher, Elke Krause, Peter Jüni |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism Pain Lichen sclerosus Sensitivity and Specificity Severity of Illness Index Vulvar Lichen Sclerosus Vulva Endocrinology Quality of life Cronbach's alpha medicine Humans 610 Medicine & health Gynecology integumentary system urogenital system business.industry Pruritus Middle Aged Vulvar cancer Vulvar intraepithelial neoplasia medicine.disease Dermatology female genital diseases and pregnancy complications Psychiatry and Mental health Dyspareunia medicine.anatomical_structure Reproductive Medicine Female Vulvar Disorder business |
| Zdroj: | The Journal of Sexual Medicine. 9:2342-2350 |
| ISSN: | 1743-6095 |
| DOI: | 10.1111/j.1743-6109.2012.02814.x |
| Popis: | Introduction Vulvar lichen sclerosus (LS) is a chronic inflammatory and mutilating disease, which goes often undetected for years. Advanced disease severely affects quality of life like sexual disorders and is also associated with an increased risk of vulvar cancer. Aim To develop and validate a patient‐administered symptom score and a physician‐administered clinical score for the diagnosis and evaluation of vulvar LS. Methods We included 24 patients with established LS diagnosis and 49 with other vulvar disease. The physician‐administered score was based on six clinical features and the patient‐administered score was a symptom‐based four‐item composite score. We determined inter‐item correlations and internal consistency of both scores, and estimated sensitivities, specificities, likelihood ratios, and posttest probabilities for different cutoffs of the physician‐administered score. Main Outcome Measures Characteristics of patients with and without LS were compared using χ 2 and unpaired t ‐test as required. We then determined Cronbach's alpha as a measure of the overall consistency of scores and calculated positive and negative likelihoods. Results Lack of redundancy of items (correlation coefficients Conclusion Scores may be useful for assessing symptoms of vulvar disorders, to ease diagnosis of LS and to evaluate treatment response over time. Gunthert AR, Duclos K, Jahns BG, Krause E, Amann E, Limacher A, Mueller MD, and Juni P. Clinical scoring system for vulvar lichen sclerosus. J Sex Med 2012;9:2342–2350. |
| Databáze: | OpenAIRE |
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