S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants
| Autor: | Chiara Strozzi, Giuseppe Lapergola, Bashir Moataza, Alessandro Graziosi, Marika Perrotta, Darek Gruzfeld, Milena Catenaro, Natalia Chukhlantseva, Ebe D'Adamo, Rita Salomone, Giovanni Livolti, Antonio Maconi, Caterina Di Battista, Giacomo Centini, Francesco Chiarelli, Immacolata Savarese, Hanna Aboulgar, Diego Gazzolo, Lucia Gabriella Tina, Mariangela Conte, Francesco D'Antonio, Iman Iskander, Andrea Dotta, Massimo Caulo, Francesco Nigro, Iliana Bersani, Danilo Gavilanes, Hala Mufeed, Giorgia Gasparroni, Gabriella Levantini, Adele Patrizia Primavera, Daniele Panichi, Maria Kornacka, Fabio Galvano |
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| Přispěvatelé: | RS: MHeNs - R3 - Neuroscience, RS: GROW - R4 - Reproductive and Perinatal Medicine, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Standard of care BIRTH Clinical Biochemistry Cerebral ultrasound Early detection Infant Premature Diseases S100 Calcium Binding Protein beta Subunit cerebral ultrasound TERM intraventricular hemorrhage S100B 03 medical and health sciences 0302 clinical medicine Corrected Gestational Age medicine Humans magnetic resonance imaging preterm infants S100b protein GESTATIONAL-AGE medicine.diagnostic_test business.industry S100-BETA PROTEIN Biochemistry (medical) Infant Newborn Brain Infant Magnetic resonance imaging General Medicine medicine.disease Intraventricular hemorrhage Cerebral mri Case-Control Studies 030220 oncology & carcinogenesis Radiology business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Clinical Chemistry and Laboratory Medicine, 59(9), 1527-1534. Walter de Gruyter GmbH |
| ISSN: | 1437-4331 1434-6621 |
| Popis: | Objectives The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures. Methods We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40–42 weeks of corrected gestational age. Results Elevated (p Conclusions The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B. |
| Databáze: | OpenAIRE |
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