Electroactive Mg2+-Hydroxyapatite Nanostructured Networks against Drug-Resistant Bone Infection Strains
| Autor: | Paula V. Messina, Nancy Carolina Andrés, Carlos Hernán Rodríguez, Mónica Diana Baldini, Juan Manuel Sieben, Angela Famiglietti |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science Population INGENIERÍAS Y TECNOLOGÍAS 02 engineering and technology medicine.disease_cause Microbiology Bone Infection 03 medical and health sciences IMPLANT medicine General Materials Science Otras Nanotecnología education Escherichia coli Nanotecnología education.field_of_study biology Pseudomonas aeruginosa 021001 nanoscience & nanotechnology biology.organism_classification HYDROXYAPATITE MAGNESIUM SUBSTITUTION 030104 developmental biology INFECTIONS Staphylococcus aureus ANTIBACTERIAL EFFECTS Implant 0210 nano-technology Wound healing Bacteria |
| Zdroj: | ACS Applied Materials & Interfaces. 10:19534-19544 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Surface colonization competition between bacteria and host cells is one of the critical factors involved in tissue/implant integration. Current biomaterials are evaluated for their ability both of withstanding favorable responses of host tissue cells and of resisting bacterial contamination. In this work, the antibacterial ability of biocompatible Mg2+-substituted nanostructured hydroxyapatite (HA) was investigated. The densities of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli strains were significantly decreased after culture in the presence of Mg-substituted HA materials in direct correlation with Mg2+-Ca2+ switch in the HA lattice. It was noticed that this decrease was accompanied by a minimal alteration of bacterial environments; therefore, the Mg2+-HA antibacterial effect was associated with the material surface topography and it electroactive behavior. It was observed that 2.23 wt % Mg2+-HA samples exhibited the best antibacterial performance; it decreased 2-fold the initial population of E. coli, P. aeruginosa, and S. aureus at the intermediate concentration (50 mg mL-1 of broth). Our results reinforce the potential of Mg-HA nanostructured materials to be used in antibacterial coatings for implantable devices and/or medicinal materials to prevent bone infection and to promote wound healing Fil: Andrés, Nancy Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Sieben, Juan Manuel. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Unidad de Direccion; Argentina Fil: Baldini, Monica Diana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Rodríguez, Carlos H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Famiglietti, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Messina, Paula Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|