Induction of erythroid differentiation in murine erythroleukemia cells by N-substituted polymethylene diamides
| Autor: | Toyoharu Hozumi, Minoru Ishizawa, Junko Nomura |
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| Rok vydání: | 1979 |
| Předmět: |
Cancer Research
Erythrocytes Leukemia Experimental Chemistry Potent inducer Hemoglobin synthesis Cell growth rate Amides Hexamethylene bisacetamide Cell Line Hemoglobins Mice chemistry.chemical_compound Oncology Biochemistry hemic and lymphatic diseases Amide Animals Potency Leukemia Erythroblastic Acute Hemoglobin Cells Cultured |
| Zdroj: | International Journal of Cancer. 23:119-122 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910230121 |
| Popis: | Various N-substituted polymethylene diamides were synthesized and tested for their potency to induce erythroid differentiation in murine erythroleukemia cells. N,N,N',N'-tetramethyl-1.6-hexane-dicarboxamide (IIc) was the most potent inducer among 15 compounds tested. The effectiveness of this compound was similar to that of hexamethylene bisacetamide (HMBA). HMBA has a different amide linkage order from that of IIc. HMBA and IIc at a concentration of 5 mM had similar effects on the cell growth rate and induced a similar frequency of benzidine-positive cells. However, hemoglobin production was 1.5 times more effective with IIc. Polymethylene diester, diamide, dihydrazide and dianilide had no effect on the induction of hemoglobin synthesis. The N-alkylated amide group appears to be required for induction of differentiation in murine erythroleukemia cells. |
| Databáze: | OpenAIRE |
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