Hepatobiliary laboratory abnormalities among patients with chronic or persistent immune thrombocytopenia (ITP)
| Autor: | Andrew T. McAfee, Katie L Dawson, Dimitri Bennett, Dickens Theodore, Cheryl Enger, Manuel Aivado |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Retrospective cohort study medicine.medical_specialty Adolescent Biliary Tract Diseases Population Specialties of internal medicine Autoimmunity Comorbidity Gastroenterology Liver function Young Adult Liver disease Liver Function Tests Internal medicine Diabetes mellitus Epidemiology Prevalence medicine Humans education Aged Retrospective Studies Aged 80 and over Purpura Thrombocytopenic Idiopathic education.field_of_study Hepatology business.industry Incidence Liver Diseases Incidence (epidemiology) General Medicine Middle Aged medicine.disease Thrombocytopenia RC581-951 Chronic Disease Cohort Immunology Female business Follow-Up Studies |
| Zdroj: | Annals of Hepatology, Vol 10, Iss 2, Pp 188-195 (2011) |
| ISSN: | 1665-2681 |
| Popis: | Therapies for immune thrombocytopenia (ITP) may be associated with abnormal hepatobiliary laboratory (HBL) values, but the epidemiology of these abnormalities is unknown in the ITP population. The study aim was to provide prevalence and incidence rates, as well as risk factors for abnormal HBL values among a cohort of patients with chronic or persistent primary ITP. Health insurance claims data from 3,244 patients with chronic or persistent ITP was examined to estimate the prevalence of abnormal HBL values: elevated levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), total bilirubin, and Alkaline Phosphatase (ALP). Incidence of abnormal HBL values was estimated in a sub cohort of 2557 (79%) patients without evidence of comorbidities related to secondary thrombocytopenia, liver disease, or abnormal HBL values during the 12-month baseline period. The baseline prevalence of ALT and AST > 3x the upper limit of normal (ULN) was 4.6 and 3.7%, respectively. The baseline prevalence of total bilirubin and ALP >1.5x ULN was 4.2 and 3.2%, respectively. The incidence rate of new HBL abnormalities (HBLA) was 1.24/1,000 person- years (95% CI: 0.52-2.56) for ALT>3x ULN and 0.41/1,000 person-years (95% CI: 0.08-1.32) for AST>3x ULN. HBLAs were significantly associated with male gender, liver disease, diabetes, congestive heart failure, lupus, hematological cancers, and HIV infection. In conclusion, the prevalence of HBLA, specifically ALT>3x ULN, among the ITP population is relatively high compared with atrial fibrillation, though within the confidence interval for that estimate. HBLAs were significantly associated with male gender, liver disease, and several other comorbidities, thus, distinguishing drug-induced liver injury in this population is clinically challenging. |
| Databáze: | OpenAIRE |
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