Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice
| Autor: | Yasushi Kuraishi, Tsugunobu Andoh, Ayako Harada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
keratinocytes 0301 basic medicine Sensory Receptor Cells leukotrieneB medicine.drug_class Leukotriene B4 Receptors Leukotriene B4 interleukin-31 Dermatology Pharmacology 03 medical and health sciences Histamine receptor chemistry.chemical_compound Anti-Allergic Agents medicine Animals Lipoxygenase Inhibitors itch Receptor Cells Cultured Skin Mice Inbred ICR Oncostatin M Receptor beta Subunit Behavior Animal business.industry Interleukins Pruritus Antagonist Interleukin Receptors Interleukin General Medicine Zileuton Receptor antagonist dorsalrootganglia Disease Models Animal 030104 developmental biology Interleukin 31 chemistry RL1-803 Leukotriene Antagonists scratching business Signal Transduction medicine.drug |
| Zdroj: | Acta Dermato-Venereologica, Vol 97, Iss 8, Pp 922-927 (2017) |
| ISSN: | 0001-5555 |
| Popis: | A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves. However, the underlying peripheral mechanisms of IL-31-induced itch in the skin remain unclear. Therefore, the present study investigated the peripheral mechanisms underlying IL-31-induced itch in mice. IL-31-induced itch-related response was inhibited by anti-allergic drugs (tranilast and azelastine), but not by an H1 histamine receptor antagonist (terfenadine). Furthermore, a 5-lipoxygenase inhibitor (zileuton), but not a cyclooxygenase inhibitor (indomethacin), and a leuko-triene B4 (LTB4) receptor antagonist (CMHVA) attenuated the action of IL-31. IL-31 receptor-immunoreactivity was observed in the epidermis and primary sensory neurones. IL-31 receptor mRNA was expressed in mouse keratinocytes and dorsal root ganglia neurones. IL-31 increased the production of LTB4 in mouse keratinocytes. These results suggest that IL-31 elicits itch not only through direct action on primary sensory neurones, but also by inducing LTB4 production in keratinocytes. |
| Databáze: | OpenAIRE |
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