Persistent schema-dependent hippocampal-neocortical connectivity during memory encoding and postencoding rest in humans
| Autor: | Erno J. Hermans, Marlieke T. R. van Kesteren, Guillén Fernández, David G. Norris |
|---|---|
| Přispěvatelé: | Educational Studies |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Time Factors Adolescent Computer science Models Neurological Neocortex Hippocampal formation Neuroinformatics [DCN 3] Research Support Brain mapping Models Biological Hippocampus 150 000 MR Techniques in Brain Function Cognition Memory Models Encoding (memory) Schema (psychology) 130 000 Cognitive Neurology & Memory medicine Journal Article Humans Prefrontal cortex Non-U.S. Gov't Brain Mapping Multidisciplinary medicine.diagnostic_test Research Support Non-U.S. Gov't Brain Biological Sciences 130 030 The schema-consolidation hypothesis Biological Magnetic Resonance Imaging 130 026 VENI Hermans ‘In a fit of fear’ medicine.anatomical_structure Neurological Female Functional magnetic resonance imaging Neuroscience Functional Neurogenomics [DCN 2] |
| Zdroj: | Proceedings of the National Academy of Sciences USA, 107, 7550-5 Proceedings of the National Academy of Sciences USA, 107, 16, pp. 7550-5 van Kesteren, M T R, Fernández, G, Norris, D G & Hermans, E J 2010, ' Persistent schema-dependent hippocampal-neocortical connectivity during memory encoding and postencoding rest in humans ', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 16, pp. 7550-5 . https://doi.org/10.1073/pnas.0914892107 Proceedings of the National Academy of Sciences of the United States of America, 107(16), 7550-5. National Acad Sciences |
| ISSN: | 0027-8424 |
| DOI: | 10.1073/pnas.0914892107 |
| Popis: | Contains fulltext : 89760.pdf (Publisher’s version ) (Closed access) The hippocampus is thought to promote gradual incorporation of novel information into long-term memory by binding, reactivating, and strengthening distributed cortical-cortical connections. Recent studies implicate a key role in this process for hippocampally driven crosstalk with the (ventro)medial prefrontal cortex (vmPFC), which is proposed to become a central node in such representational networks over time. The existence of a relevant prior associative network, or schema, may moreover facilitate this process. Thus, hippocampal-vmPFC crosstalk may support integration of new memories, particularly in the absence of a relevant prior schema. To address this issue, we used functional magnetic resonance imaging (fMRI) and prior schema manipulation to track hippocampal-vmPFC connectivity during encoding and postencoding rest. We manipulated prior schema knowledge by exposing 30 participants to the first part of a movie that was temporally scrambled for 15 participants. The next day, participants underwent fMRI while encoding the movie's final 15 min in original order and, subsequently, while resting. Schema knowledge and item recognition performance show that prior schema was successfully and selectively manipulated. Intersubject synchronization (ISS) and interregional partial correlation analyses furthermore show that stronger prior schema was associated with more vmPFC ISS and less hippocampal-vmPFC interregional connectivity during encoding. Notably, this connectivity pattern persisted during postencoding rest. These findings suggest that additional crosstalk between hippocampus and vmPFC is required to compensate for difficulty integrating novel information during encoding and provide tentative support for the notion that functionally relevant hippocampal-neocortical crosstalk persists during off-line periods after learning. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|