CA-15.3, TPA and MCA as markers for breast cancer
| Autor: | J. Abrahamson, M. Steiner, B. Finkel, S. Antal, N. Gruener, M. Barak |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Pathology Tissue Polypeptide Antigen CA 15-3 Breast Neoplasms Cancer detection Gastroenterology Breast Diseases Breast cancer Antigen Antigens Neoplasm Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans Antigens Tumor-Associated Carbohydrate business.industry Serum concentration medicine.disease Predictive value Oncology Female Breast disease Peptides business |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 26:577-580 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(90)90081-4 |
| Popis: | Serum concentrations of CA-15.3, tissue polypeptide antigen (TPA) and mucinous-like carcinoma-associated antigen (MCA) were measured in 327 women: 81 controls, 93 patients with benign breast disease, 46 patients recently diagnosed with breast cancer and 107 patients during breast cancer follow-up. CA-15.3 was elevated in 16% of the controls, in 29% of the patients with benign breast disease, in 65% of the breast cancer patients and in 74% of the follow-up patients. TPA was elevated in 4%, 11%, 36% and 75%, respectively. The corresponding figures for MCA were 10%, 8%, 30% and 64%. The highest sensitivity for cancer detection (74%) was obtained with a combination of CA-15.3 and TPA, while the specificity of this panel was 75%. The negative predictive value of these combined tests was 93%. MCA scored lower values, being only 30% sensitive. The CA-15.3/TPA panel may increase sensitivity compared with single marker tests and provide additional information for clinical evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|