Basic science review of birth tissue uses in ophthalmology
| Autor: | Sean Tighe, Scheffer C.G. Tseng, Olivia G Mead, Amy Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Fetus Basic science business.industry Cell Amniotic membrane PTX3 Review Article Matrix (biology) Umbilical cord Cryopreservation 03 medical and health sciences ophthalmology 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure lcsh:Ophthalmology lcsh:RE1-994 Ophthalmology 030221 ophthalmology & optometry medicine umbilical cord business Pentraxin-3 |
| Zdroj: | Taiwan Journal of Ophthalmology Taiwan Journal of Ophthalmology, Vol 10, Iss 1, Pp 3-12 (2020) |
| ISSN: | 2211-5072 |
| Popis: | The birth tissue is predominantly comprised of amniotic membrane (AM) and umbilical cord (UC), which share the same cell origin as the fetus. These versatile biological tissues have been used to treat a wide range of conjunctival and corneal conditions since 1940. The therapeutic benefits of the birth tissue stem from its anti-inflammatory and anti-scarring properties that orchestrate regenerative healing. Although the birth tissue also contains many cytokines, growth factors, and proteins, the heavy chain 1-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) matrix has been identified to be a major active tissue component responsible for AM/UC's multifactorial therapeutic actions. HC-HA/PTX3 complex is abundantly present in fresh and cryopreserved AM/UC, but not in dehydrated tissue. In this review, we discuss the tissue anatomy, the molecular mechanism of action based on HC-HA/ PTX3 to explain their therapeutic potentials, and the various forms available in ophthalmology. |
| Databáze: | OpenAIRE |
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