A transcallosal fibre system between homotopic inferior frontal regions supports complex linguistic processing
| Autor: | Tonio Ball, Philipp Kellmeyer, Magnus-Sebastian Vry |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Research Report Genu of the corpus callosum Deep linguistic processing Cognitive Neuroscience Corpus callosum Paralanguage Corpus Callosum 03 medical and health sciences 0302 clinical medicine Linguistic sequence complexity linguistic complexity medicine Connectome homotopic Humans 030304 developmental biology Language 0303 health sciences General Neuroscience language processing Cognition Human brain diffusion tensor imaging Frontal Lobe medicine.anatomical_structure Speech Perception Female Psychology Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | The European Journal of Neuroscience |
| ISSN: | 1460-9568 |
| Popis: | Inferior frontal regions in the left and right hemisphere support different aspects of language processing. In the canonical model, left inferior frontal regions are mostly involved in processing based on phonological, syntactic and semantic features of language, whereas the right inferior frontal regions process paralinguistic aspects like affective prosody. Using diffusion tensor imaging (DTI)‐based probabilistic fibre tracking in 20 healthy volunteers, we identify a callosal fibre system connecting left and right inferior frontal regions that are involved in linguistic processing of varying complexity. Anatomically, we show that the interhemispheric fibres are highly aligned and distributed along a rostral to caudal gradient in the body and genu of the corpus callosum to connect homotopic inferior frontal regions. In the light of converging data, taking previous DTI‐based tracking studies and clinical case studies into account, our findings suggest that the right inferior frontal cortex not only processes paralinguistic aspects of language (such as affective prosody), as purported by the canonical model, but also supports the computation of linguistic aspects of varying complexity in the human brain. Our model may explain patterns of right‐hemispheric contribution to stroke recovery as well as disorders of prosodic processing. Beyond language‐related brain function, we discuss how inter‐species differences in interhemispheric connectivity and fibre density, including the system we described here may also explain differences in transcallosal information transfer and cognitive abilities across different mammalian species. The integration of linguistic and paralinguistic information in speech processing requires the close interaction and coordination of left and right‐hemispheric perisylvian brain regions. This study uses probabilistic fibre tracking in diffusion tensor imaging data from healthy participants to map transcallosal homotopic fibre pathways between left and right inferior frontal cortex that are involved in speech processing of varying complexity. |
| Databáze: | OpenAIRE |
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