CA – 125, Placental Alkaline Phosphatase and Tissue Polypeptide Antigen as Preoperative Serum Markers in Ovarian Carcinoma
| Autor: | Ulla Hørding, Johannes E. Bock, Bent Nørgaard-Pedersen, Søren Daugaard, Kim Toftager-Larsen, Anne Dreisler, B Lund, Kirsten Frederiksen, Finn Lundvall |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Placenta medicine.medical_treatment Tissue Polypeptide Antigen Ovary Biology Antigens Neoplasm Laparotomy Ovarian carcinoma Biomarkers Tumor medicine Humans Antigens Tumor-Associated Carbohydrate Aged Aged 80 and over Ovarian Neoplasms Carcinoma Obstetrics and Gynecology Middle Aged Alkaline Phosphatase Adenocarcinoma Mucinous Placental alkaline phosphatase medicine.anatomical_structure Reproductive Medicine Evaluation Studies as Topic Female Tissue polypeptide Peptides Serum markers |
| Zdroj: | Gynecologic and Obstetric Investigation. 33:177-182 |
| ISSN: | 1423-002X 0378-7346 |
| Popis: | Blood samples were drawn before laparotomy in 42 cases of benign, 17 cases of borderline, and 53 cases of malignant epithelial ovarian neoplasms. The concentrations of CA-125, tissue polypeptide antigen, and placental alkaline phosphatase (PLAP) were determined. No significant difference was found between the levels of CA-125 and TPA. No significant correlation was seen between tumour type and these two markers; however, both were significantly correlated to tumour malignancy and clinical stage, and CA-125 was also correlated to tumour grade. No correlation was found between PLAP and the other markers or any of the above-mentioned parameters. If at least one of two or three markers was requested to be positive, a moderate increase in the 'detection rate' of malignant tumours was found. However, the rate of positive benign samples increased to as much as 41%. Requesting at least two markers out of two or three to be positive certainly reduced the number of 'false-positive' benign tumours, but the sensitivity for malignant tumours was reduced concomitantly to levels where marker determinations would be of little use. The study demonstrated a possible, but limited role for preoperative determinations of the markers. A combination of two or three markers was not superior to single markers. The results indicate that neither of these markers will be of significant value in a screening context. |
| Databáze: | OpenAIRE |
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