How does comorbid bronchiectasis affect asthmatic patients? A meta-analysis
| Autor: | Guochao Shi, Yingmeng Ni, Yahui Liu, Chunrong Huang, Yun Feng, Gelei Lan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Affect (psychology) Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Asthmatic patient Humans 030212 general & internal medicine Asthma Bronchiectasis business.industry Age Factors medicine.disease Pathophysiology Respiratory Function Tests Hospitalization Observational Studies as Topic 030228 respiratory system Meta-analysis Pediatrics Perinatology and Child Health Etiology business |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 58(10) |
| ISSN: | 1532-4303 |
| Popis: | Asthma and bronchiectasis are known to be two distinct diseases with different etiology, pathophysiology, management, and prognosis. However, a high prevalence of bronchiectasis has been reported in patients with severe asthma. Thus, it is of great importance to identify the impact of bronchiectasis on asthmatic patients.Databases including PubMed, Embase, Cochrane, Web of Science were searched comprehensively to identify relevant human clinical studies published until February 2020.Two investigators (Gelei Lan and Guochao Shi) independently obtained the potentially eligible articles based on their titles and abstracts. When opinions differed between the investigators, discussions were made to reach an agreement. The authors of the included studies were contacted for inquiry when necessary.Six observational studies with 1004 patients were included in the meta-analysis. The mean prevalence of bronchiectasis in patients with asthma was 35.2% (ranging from 2.2% to 47%). Asthmatic patients with bronchiectasis were older, had a longer disease duration, exhibited greater severity, and showed more frequent exacerbations and hospitalization, and poorer lung function, compared with the patients without bronchiectasis.Despite of the heterogeneity between included studies and detectable publication bias, this meta-analysis demonstrated the impact of comorbid bronchiectasis on asthmatic patients. Thus, coexistence of bronchiectasis should be considered a clinical phenotype of asthma, which may have associations with exacerbation and hospitalization. |
| Databáze: | OpenAIRE |
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