Expression of the c-jun, jun-B, ets-2 and liver regeneration factor-1 (LRF-1) genes during promotion and progression of rat liver carcinogenesis in the resistant hepatocyte model
| Autor: | Inger Porsch Hällström, De Zhong Liao, Agneta Blanck, Jan-Åke Gustafsson |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Proto-Oncogene Proteins c-jun Gene Expression Biology medicine.disease_cause Proto-Oncogene Protein c-ets-2 chemistry.chemical_compound Liver Neoplasms Experimental Genes jun Proto-Oncogene Proteins Internal medicine Gene expression medicine Animals Rats Wistar Activating Transcription Factor 3 c-jun 2-Acetylaminofluorene Liver regeneration Rats DNA-Binding Proteins Repressor Proteins Disease Models Animal Endocrinology medicine.anatomical_structure Liver Oncology chemistry Tumor progression Hepatocyte Carcinogens Disease Progression Trans-Activators Female Tumor promotion Carcinogenesis Transcription Factors |
| Zdroj: | Cancer Letters. 100:215-221 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(95)04088-9 |
| Popis: | During promotion in the RH-model, the mRNA expression of c-jun and LRF-1 was 2- to 8-fold elevated in both initiated and uninitiated rats receiving 2-AAF. The increase was more pronounced in male than in female rats, and GH treatment of male rats down-regulated the expression towards the level in females. The level in uninitiated 2-AAF-treated livers was as high as in isolated early nodules. jun-B also showed 3- to 8-fold increased expression, but without sex differences. An increased nuclear transcription of the LRF-1 and jun-B genes but not of c-jun was observed. During progression, LRF-1 and ets-2 showed a 2- to 3-fold higher expression in persistent nodules and hepatocellular carcinomas than in the corresponding surrounding liver tissues, whereas the expression of the jun genes was 3- to 4-fold increased both in lesions and in surrounding livers when compared to age-matched control rats. In conclusion, while the changes during promotion might not be connected with control of early focal growth, the increased levels of LRF-1 and ets-2 in advanced lesions might indicate that these genes could contribute to the growth advantage for persistent nodules during progression. |
| Databáze: | OpenAIRE |
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