Metabolism of Thiamine-S35 in the Rabbit
| Autor: | Verrett Mj, Leopold R. Cerecedo |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
medicine.medical_specialty
Chemistry Urinary system Stomach Urine General Biochemistry Genetics and Molecular Biology Excretion chemistry.chemical_compound Endocrinology medicine.anatomical_structure Oral administration Internal medicine medicine Animals Thiamine Rabbits Intramuscular injection Thiazole |
| Zdroj: | Experimental Biology and Medicine. 98:509-513 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-98-24091 |
| Popis: | SummaryThe fate of thiamine, labeled with sulfur-35 in the thiazole moiety, has been studied in rabbits after oral and parenteral administration of doses in the physiological range. Analyses of the urinary and fecal sulfur fractions for 4 to six 24-hour periods following administration of radiovitamin, gave average total recovery of radiosulfur of 77% after administration by stomach tube, 86% after intramuscular injection, and 54% after intravenous injection. When oral dose of radiovitamin was followed 6 hours later by intramuscular injection of a 20-fold larger dose of non-radioactive thiamine, an additional 17% of radiosulfur was recovered in urine. In all cases, the neutral sulfur fraction of urine contained more than 50% of the recovered radiosulfur, and the greater portion of this was excreted in the first 24-hour period following administration of radiovitamin. Isolation of main metabolites following oral administration indicates that unchanged thiamine-S35 and thiazole S35 moiety together account f... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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