ALTERED CIRCULATING LEVELS OF RETINOL BINDING PROTEIN 4 AND TRANSTHYRETIN IN RELATION TO INSULIN RESISTANCE, OBESITY, AND GLUCOSE INTOLERANCE IN ASIAN INDIANS
| Autor: | Kuppan Gokulakrishnan, Ranjit Mohan Anjana, Viswanathan Mohan, Anand Kaviya, Mahalingam Balakumar, Priya Miranda, M. Balasubramanyam, Kaliyaperumal Velmurugan, Gautam Kumar Pandey, Mohan Deepa, Shiny Abhijit, Jayashree Balasubramanyam |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism India Impaired glucose tolerance Prediabetic State Endocrinology Insulin resistance Diabetes mellitus Internal medicine Glucose Intolerance Medicine Humans Prealbumin Prediabetes Obesity Aged Retinol binding protein 4 biology business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Transthyretin Retinol binding protein Diabetes Mellitus Type 2 biology.protein Female Insulin Resistance business Retinol-Binding Proteins Plasma |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 21(8) |
| ISSN: | 1530-891X |
| Popis: | Retinol binding protein 4 (RBP4) has been implicated in metabolic disorders including type 2 diabetes mellitus (T2DM), but few studies have looked at transthyretin (TTR) with which RBP4 is normally bound to in the circulation. We report on the systemic levels of RBP4 and TTR and their associations with insulin resistance, obesity, prediabetes, and T2DM in Asian Indians.Age-matched individuals with normal glucose tolerance (NGT, n = 90), impaired glucose tolerance (IGT, n = 70) and T2DM (n = 90) were recruited from the Chennai Urban Rural Epidemiology Study (CURES). Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). RBP4 and TTR levels were measured by enzyme-linked immunosorbent assay (ELISA).Circulatory RBP4 and TTR levels (in μg/mL) were highest in T2DM (RBP4: 13 ± 3.9, TTR: 832 ± 310) followed by IGT (RBP4: 10.5 ± 3.2; TTR: 720 ± 214) compared to NGT (RBP4: 8.7 ± 2.5; TTR: 551 ± 185; P.001). Compared to nonobese NGT individuals, obese NGT, nonobese T2DM, and obese T2DM had higher RBP4 (8.1 vs. 10.6, 12.1, and 13.2 μg/mL, P.01) and TTR levels (478 vs. 737, 777, and 900 μg/mL, P.01). RBP4 but not TTR was significantly (P.001) correlated with insulin resistance even among NGT subjects. In regression analysis, RBP4 and TTR showed significant associations with T2DM after adjusting for confounders (RBP4 odds ratio [OR]: 1.107, 95% confidence interval [CI]: 1.008-1.216; TTR OR: 1.342, 95% CI: 1.165-1.547).Circulatory levels of RBP4 and TTR showed a significant associations with glucose intolerance, obesity, T2DM and RBP4 additionally, with insulin resistance. |
| Databáze: | OpenAIRE |
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