Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study
| Autor: | Hanumanthappa Nandeesha, Ann Prasad Mary, Rajesh Nachiappa Ganesh, Vikas Menon, Thyagaraju Chitra, Dasari Papa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Infertility
030219 obstetrics & reproductive medicine QH471-489 medicine.diagnostic_test Cross-sectional study business.industry Reproduction Obstetrics and Gynecology Physiology Perceived Stress Scale Interleukin Gynecology and obstetrics Semen analysis medicine.disease Male infertility Pathogenesis 03 medical and health sciences 0302 clinical medicine Reproductive Medicine infertility interleukins peptide hydrolase RG1-991 medicine 030212 general & internal medicine Interleukin 17 business |
| Zdroj: | International Journal of Reproductive BioMedicine, Vol 19, Pp 333-338 (2021) |
| ISSN: | 2476-3772 2476-4108 |
| DOI: | 10.18502/ijrm.v19i4.9059 |
| Popis: | Background: Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and psychological stress are known to play a role in the pathogenesis of male infertility. Objective: To assess the association of MMP-9 with IL-17 and psychological stress in infertile men. Materials and Methods: In this cross-sectional study, 39 men with infertility diagnosed based on semen analysis and 39 subjects with normal semen analysis were included in the study. MMP-9 and IL-17 were estimated in both groups by ELISA. Perceived stress scale was used to assess psychological stress in controls and cases. Results: In infertile cases, MMP-9 and IL-17 were significantly increased when compared with controls (p = 0.046, p = 0.041 respectively). A significant association of MMP-9 was observed with IL-17 (r = 0.335, p = 0.037) and perceived stress scale (r = 0.329, p = 0.041). Conclusion: IL-17 and stress increase MMP- 9 levels in infertile men. Key words: Infertility, Interleukins, Peptide hydrolase. |
| Databáze: | OpenAIRE |
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