Folic Acid Supplement Intake in Early Pregnancy Increases Risk of Gestational Diabetes Mellitus: Evidence From a Prospective Cohort Study
| Autor: | Shuangqin Yan, Sanhuan Huang, Fangbiao Tao, Ying Niu, Beibei Zhu, Leijing Mao, Shilu Tong, Yeqing Xu, Peng Zhu, Jiahu Hao, Kun Huang, Xing Ge |
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| Rok vydání: | 2016 |
| Předmět: |
Advanced and Specialized Nursing
Pregnancy Respiratory tract infections Offspring business.industry Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism medicine.disease Gestational diabetes 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal Medicine medicine 030212 general & internal medicine Prospective cohort study Adverse effect business |
| Zdroj: | Diabetes Care. 39:e36-e37 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc15-2389 |
| Popis: | Folic acid (FA) is well known for its preventive effect on neural tube defects, and recommendations for FA supplement before and during pregnancy have been well established all over the world. Since increased consumption of FA has been prevalent, concerns about its negative consequences have been raised. Diverse adverse effects of FA have been identified, ranging from an increased risk of oral cleft malformations, asthma/respiratory tract infections, and small-for-gestational-age infants to the more serious effect of a potential increased risk of cancers. Previous studies have suggested that a high maternal folate concentration is associated with an increased risk of insulin resistance in children and gestational diabetes mellitus (GDM) (1). In addition, animal experiments have reported that maternal high-FA supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet (2). However, … |
| Databáze: | OpenAIRE |
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