Apolipoprotein E genotype and psychosis
| Autor: | Shinichi Sakamoto, Taihei Miyakawa, Takemi Kimura, Kouko Ishizuka, Junichi Takamatsu, Tomohide Igata, Shoichi Katsuragi, Ruriko Igata-Yi |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Apolipoprotein E Psychosis medicine.medical_specialty Adolescent Apolipoprotein E4 Polymerase Chain Reaction Apolipoproteins E Internal medicine Chromosome 19 medicine Humans In patient Allele Child Psychiatry Allele frequency Alleles Biological Psychiatry Aged Aged 80 and over Polymorphism Genetic Dementia Vascular Late paraphrenia Middle Aged medicine.disease Increased risk Endocrinology Psychotic Disorders Schizophrenia Female lipids (amino acids peptides and proteins) Psychology |
| Zdroj: | Biological Psychiatry. 41:906-908 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/s0006-3223(97)00015-2 |
| Popis: | Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD). Many papers show linkage of the presence of Apo E-e4 and late-onset AD (Corder et al 1993; Nalbantoglu et al 1994; Noguchi et al 1993; Saunders et al 1993; Strittmatter et al 1993; Yoshizawa et al 1994); however, the frequency of the Apo E-e4 was low in "schizophrenics with progressive dementia" and late paraphrenia (Martiuoli et al 1995; Howard et al 1995). In contrast, Harrington et al reported that Apo E-e4 allele frequency was increased in patients with schizophrenia (Harrington et al 1995). Thus, we determined the Apo E genotype in patients with schizophrenia whose status had been strictly diagnosed and investigated the association of the Apo E-e4 allele and schizophrenia. |
| Databáze: | OpenAIRE |
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