Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

Autor: J.P. Deslypere, W.L. Blok, M.P.C. Hectors, J.W.M. van der Meer, J. van der Ven-Jongekrijg, Pierre N.M. Demacker, M.B. Katan
Přispěvatelé: Faculty of Science
Rok vydání: 1997
Předmět:
Male
The effect of modulation of endogenous cytokines on resistance to infection
medicine.medical_treatment
Clinical Biochemistry
Interleukin 6
Cholesterolmetabolisme en cytokinen
Interleukin 1
Biochemistry
GeneralLiterature_REFERENCE(e.g.
dictionaries
encyclopedias
glossaries)
Human Nutrition & Health
Aged
80 and over
chemistry.chemical_classification
biology
Humane Voeding & Gezondheid
Interleukin
General Medicine
Middle Aged
Fish oil
Het effect van modulatie van endogene cytokinen op weerstand tegen infecties
Fish ails
Cytokines
Adult
medicine.medical_specialty
Sialoglycoproteins
Interleukin-1 receptor
Fish Oils
Internal medicine
medicine
Humans
Cholesterol metabolism and cytokines
Aged
VLAG
Inflammation
Tumor Necrosis Factor-alpha
Vitamin E
N-3 polyunsaturated fatty acids
Fatty acid
Interleukin 1 Receptor Antagonist Protein
Endocrinology
Interleukin 1 receptor antagonist
Human nutrition
Interleukin-l receptor
chemistry
Dietary Supplements
Immunology
biology.protein
Patient Compliance
Tumour necrosis factor
Interleukin-1
Zdroj: European Journal of Clinical Investigation, 27, pp. 1003-1008
European Journal of Clinical Investigation, 27, 1003-8. Wiley-Blackwell Publishing
European Journal of Clinical Investigation, 27, 1003-1008
European Journal of Clinical Investigation, 27, 12, pp. 1003-1008
Blok, W L, Deslypere, J P, Demacker, P N M, van der Ven-Jongekrijg, J, Hectors, M P C, van der Meer, J W M & Katan, M B 1997, ' Pro and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year ', European Journal of Clinical Investigation, vol. 27, pp. 1003-8 . https://doi.org/10.1046/j.1365-2362.1997.2240775.x
European Journal of Clinical Investigation 27 (1997)
ISSN: 1365-2362
0014-2972
DOI: 10.1046/j.1365-2362.1997.2240775.x
Popis: Dietary supplementation with n-3 fatty acids from fish oil alleviates inflammation in various chronic inflammatory disease states. Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. We investigated long-term effects of dietary n-3 fatty acids on circulating cytokine concentrations and on ex vivo stimulated whole-blood production of IL-1 beta, TNF-alpha and interleukin 1 receptor antagonist (IL-1Ra), the naturally occurring antagonist of IL-1. A total of 58 monks with a mean age of 56 years were randomized into four groups and their diets were supplemented with 0, 3, 6, or 9 g of fish oil, providing 0, 1.06, 2.13 or 3.19 g of n-3 fatty acids per day. Subjects received equal amounts of saturated fatty acids, vitamin E and cholesterol. Compliance was excellent and erythrocyte fatty acid profiles closely reflected the amounts of n-3 fatty acids ingested. In the group receiving 9 g of fish oil per day, no influence of n-3 fatty acids on circulating cytokine concentrations was observed relative to placebo. Endotoxin-stimulated whole-blood cytokine production was measured at 26 and 52 weeks after the start and at 4, 8 and 26 weeks after cessation of supplementation. In all groups, the production of IL-1 beta and IL-1Ra was higher during supplementation than afterwards. However, no differences in cytokine production were noted between the placebo group and the various treatment groups at any point in time. Our results suggest that long-term supplementation of fish oil does not affect ex vivo cytokine production in man.
Databáze: OpenAIRE
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