Regulation of surfactant secretion in alveolar type II cells
| Autor: | Mikhail A. Kutuzov, Alexandra V. Andreeva, Tatyana A. Voyno-Yasenetskaya |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Physiology Cell Pulmonary Surfactants Cell Biology Biology Lamellar granule Pulmonary Alveoli medicine.anatomical_structure Pulmonary surfactant Biochemistry Physiology (medical) Organelle medicine Biophysics Animals Humans Secretion Lamellar structure Signal transduction Intracellular Signal Transduction |
| Zdroj: | American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L259-L271 |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00112.2007 |
| Popis: | Molecular mechanisms of surfactant delivery to the air/liquid interface in the lung, which is crucial to lower the surface tension, have been studied for more than two decades. Lung surfactant is synthesized in the alveolar type II cells. Its delivery to the cell surface is preceded by surfactant component synthesis, packaging into specialized organelles termed lamellar bodies, delivery to the apical plasma membrane and fusion. Secreted surfactant undergoes reuptake, intracellular processing, and finally resecretion of recycled material. This review focuses on the mechanisms of delivery of surfactant components to and their secretion from lamellar bodies. Lamellar bodies–independent secretion is also considered. Signal transduction pathways involved in regulation of these processes are discussed as well as disorders associated with their malfunction. |
| Databáze: | OpenAIRE |
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