Comparative antibacterial activity of topical antiseptic eardrops against methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa
| Autor: | Eu-Ri Jo, Sook-Jin Jang, Ju-Hwan Sim, Sung Il Cho, Ji Ae Choi, Cha Kyung Youn |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class Administration Topical Population Microbial Sensitivity Tests Acetates Quinolones medicine.disease_cause Otitis Media Suppurative Microbiology 03 medical and health sciences 0302 clinical medicine Boric Acids Antiseptic Drug Resistance Bacterial medicine Humans 030223 otorhinolaryngology education Acetic Acid education.field_of_study Pseudomonas aeruginosa business.industry General Medicine Antimicrobial Quinolone Methicillin-resistant Staphylococcus aureus Pharmaceutical Solutions Otorhinolaryngology Staphylococcus aureus Chronic Disease Pediatrics Perinatology and Child Health Anti-Infective Agents Local Antibacterial activity business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 85:80-83 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2016.03.031 |
| Popis: | Objective Aural irrigation using antiseptic solutions can be an effective medical treatment of chronic suppurative otitis media (CSOM) owing to the increasing prevalence of antibiotic-resistant CSOM infections. In the present study, we compared the antimicrobial activities of 100% Burow's solution, 50% Burow's solution, 2% acetic acid, vinegar with water (1:1), and 4% boric acid solution against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus (MSSA), quinolone-resistant Pseudomonas aeruginosa (QRPA), and quinolone-susceptible P. aeruginosa (QSPA) in vitro. Methods We examined the antimicrobial activities of five antiseptic solutions against MRSA, MSSA, QRPA, and QSPA. The antimicrobial activities of the solutions were calculated as a percentage of the surviving microorganisms by dividing the viable count in each antiseptic solution with that in control. The time (D10 value) required for each of the five solutions to inactivate 90% of the microorganism population was also investigated. Results Burow's solution exhibited the highest antimicrobial activity and the lowest D10 value against MRSA, MSSA, QRPA, and QSPA, followed by 2% acetic acid, vinegar with water (1:1), and 4% boric acid solution. Conclusion Our results indicate that Burow's solution has the most potent activity against bacteria including antibiotic-resistant strains. Twofold dilution of the solution is recommended to avoid ototoxicity. |
| Databáze: | OpenAIRE |
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