Seroprevalence of Pandemic A(H1N1) pmd09 Virus Antibodies in Mexican Health Care Workers Before and After Vaccination
| Autor: | Cuauhtémoc Arturo Juárez-Pérez, Luis Haro-García, Adolfo Chávez-Negrete, Laura Baltierra-Jasso, Francisco Raúl Sánchez-Román, Luis Fabila-Castillo, Guadalupe Aguilar-Madrid, Anastasia Magaña-Hernández, Iris Estrada-García, Fabio Salamanca-Gómez, Rosa María Ribas-Aparicio, Alicia Jiménez-Alberto, Juan A. Castelán-Vega, Vianney Ortiz-Navarrete, Vanessa Méndez-Ortega, Nicté Cervantes-Servín |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Health Personnel media_common.quotation_subject Antibodies Viral Logistic regression Virus Young Adult Influenza A Virus H1N1 Subtype Seroepidemiologic Studies Hygiene Occupational Exposure Physicians Surveys and Questionnaires Influenza Human Pandemic Health care Humans Medicine Seroprevalence Mexico Aged media_common biology business.industry Vaccination General Medicine Middle Aged Cross-Sectional Studies Logistic Models Influenza Vaccines Immunology biology.protein Blood Banks Female Antibody business Demography |
| Zdroj: | Archives of Medical Research. 46:154-163 |
| ISSN: | 0188-4409 |
| Popis: | Background and Aims In April 2009, a new strain of influenza A(H1N1) was identified in Mexico and in the U.S. In June 2009, WHO declared this a pandemic. Health care workers constituted a risk group for their close contact with infected individuals. The aim was to estimate seropositivity for A(H1N1)pdm09 in health staff at the Instituto Mexicano del Seguro Social. Methods A two-stage cross-sectional study, before and after vaccination in the same workers, was performed on a random sample of health-care workers. A socio-occupational questionnaire was applied and serum antibodies against influenza A(H1N1)pdm09 were determined through neutralization of retroviral pseudotypes; two logistic regression models for both were constructed. Results The average (median/mean) age of 1378 participants from 13 work centers was 41.7 years and 68.7% (947) were women. Seroprevalence for the first stage was 26.5% (365) (7.4–43%) vs. 20.8% (11) in a control group from the blood bank; for the second stage, the vaccinated group was 33% (215) (18.2–47%) and 27% (196) (11.6–50%) for the unvaccinated group. In regression models, seropositivity was associated with occupational exposure to suspected influenza infected patients, being physicians, and being vaccinated. Conclusions Seropositivity against pandemic virus is similar to what was reported, both for vaccinated (2.8–40.9%) and unvaccinated (18.8–64.7%). Low seroprevalence in the vaccinated group indicates that between 67% and 73% were susceptible to infection. Given the relatively low vaccine-induced seropositivity, it is imperative to increase, hygiene and safety for health staff and at-risk populations, and strengthen epidemiological surveillance. |
| Databáze: | OpenAIRE |
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