Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma
| Autor: | Rafael de Llorens, Anna Massaguer, Rosa Peracaula, Adrià Duran, Maite Albiol-Quer, Pedro Enrique Guerrero, Sílvia Barrabés, María José Ferri, Esther Llop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Glycosylation endocrine system diseases Glycoconjugate Aberrant glycosylation Disease Review chemistry.chemical_compound 0302 clinical medicine Diagnosis Pancreas cancer Early Detection of Cancer chemistry.chemical_classification biology Pancreas -- Diseases -- Diagnosis Biochemical markers Gastroenterology food and beverages General Medicine Prognosis humanities Neoplasm Proteins 030220 oncology & carcinogenesis Marcadors bioquímics Glicoproteïnes Carcinoma Pancreatic Ductal Glycan education Adenocarcinoma 03 medical and health sciences Pancreatic cancer health services administration medicine Biomarkers Tumor Humans Pàncrees -- Càncer Glycoproteins Pàncrees -- Malalties -- Diagnòstic business.industry Cancer medicine.disease Pancreatic Neoplasms 030104 developmental biology chemistry biology.protein Cancer research business Glycoprotein Biomarkers |
| Zdroj: | World Journal of Gastroenterology World Journal of Gastroenterology, 2018, vol. 24, núm. 24, p. 2537-2554 Articles publicats (D-B) Llop Escorihuela, Esther Guerrero, Pedro Enrique Duran Sidera, Adrià Barrabés Vera, Sílvia Massaguer i Vall-llovera, Anna Ferri Iglesias, María José Albiol-Quer, Maite Llorens Duran, Rafael de Peracaula Miró, Rosa 2018 Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma World Journal of Gastroenterology 24 24 2537 2554 DUGiDocs – Universitat de Girona instname |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. |
| Databáze: | OpenAIRE |
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