CYP1A1 activity in rainbow trout is inhibited by the environmental pollutant p-cresol
| Autor: | Vladimir Zlabek, Galia Zamaratskaia, Viktoriia Burkina, Sidika Sakalli |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Fish Proteins
Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Cresols 0302 clinical medicine parasitic diseases Cytochrome P-450 CYP1A1 Juvenile Animals Food science 0105 earth and related environmental sciences Pharmacology Pollutant General Medicine Fish health chemistry Aquatic environment Oncorhynchus mykiss Fish Rainbow trout Hepatic microsome p-Cresol Water Pollutants Chemical |
| Zdroj: | Environmental toxicology and pharmacology. 62 |
| ISSN: | 1872-7077 |
| Popis: | Naturally- and anthropogenically-produced cresols could pose serious risks to fish health. In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected. These results indicate that p-cresol might affect the ability of fish to metabolize numerous aromatic hydrocarbons and dioxin compounds, which are present in the aquatic environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect